Methyl salicylate
Salonpas (methyl salicylate) is a small molecule pharmaceutical. Methyl salicylate was first approved as Salonpas on 2008-02-20. It is used to treat acute pain, arthritis, back pain, contusions, and inflammation amongst others in the USA. It is known to target transient receptor potential cation channel subfamily A member 1.
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Salonpas
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Menthol
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Methyl salicylate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SALONPAS | Hisamitsu Pharmaceutical | N-022029 OTC | 2008-02-20 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 10% methyl salicylate pain relief patch | C200263 | 2024-06-27 |
| 1st medxpatch | unapproved drug other | 2025-10-31 |
| 365 whole foods market anticavity/antigingivitis mouthwash | OTC monograph not final | 2022-05-12 |
| 5kind dmso | C200263 | 2025-12-02 |
| 701 dieda zhengtong yaogao medicated | OTC monograph not final | 2019-11-13 |
| 701 dieda zhengtong yaogao medicated plaster | OTC monograph not final | 2014-06-26 |
| abejas y viboras roll on | C200263 | 2025-07-22 |
| advanced antiseptic citrus | C200263 | 2025-02-20 |
| advanced citrus antiseptic | C200263 | 2025-01-10 |
| advil targeted relief | C200263 | 2024-02-08 |
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Agency Specific
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Clinical
Clinical Trials
440 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 13 | 11 | 12 | 2 | 22 | 58 |
| Neuralgia | D009437 | EFO_0009430 | — | 3 | 10 | 7 | 6 | 13 | 37 |
| Cough | D003371 | — | R05 | 7 | 6 | — | 2 | 13 | 26 |
| Healthy volunteers/patients | — | — | — | 10 | 3 | — | 1 | 10 | 23 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | 3 | 2 | 4 | 2 | 6 | 17 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 2 | 1 | 4 | 3 | 6 | 16 |
| Postherpetic neuralgia | D051474 | — | — | 1 | 6 | 5 | 3 | 2 | 15 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | 4 | 6 | 2 | 2 | 13 |
| Rhinitis | D012220 | EFO_0008521 | J31 | 1 | 2 | 1 | 4 | 3 | 11 |
| Syndrome | D013577 | — | — | 1 | 1 | — | 2 | 6 | 9 |
Show 38 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Peripheral nervous system diseases | D010523 | — | G64 | 1 | 7 | 10 | — | 5 | 21 |
| Nervous system diseases | D009422 | — | G00-G99 | — | 5 | 7 | — | 1 | 12 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 3 | 1 | — | 5 | 10 |
| Neck pain | D019547 | — | M54.2 | — | 1 | 1 | — | 7 | 9 |
| Acute pain | D059787 | — | R52 | 1 | 1 | 2 | — | 4 | 7 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 4 | 3 | — | — | 7 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 2 | 2 | — | — | 5 |
| Capsicum | D002212 | — | — | — | — | 1 | — | 4 | 5 |
| Motor activity | D009043 | EFO_0003940 | — | 1 | — | 1 | — | 3 | 5 |
| Chronic pain | D059350 | — | — | — | — | 1 | — | 4 | 5 |
Show 23 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic cough | D000096822 | — | R05.3 | 3 | 1 | — | — | 9 | 13 |
| Deglutition disorders | D003680 | — | R13.1 | — | 2 | — | — | 8 | 10 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 3 | — | — | 5 | 9 |
| Pruritus | D011537 | — | L29 | 1 | 1 | — | — | 5 | 6 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | 1 | — | — | 4 | 5 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 1 | — | — | 4 | 5 |
| Postoperative pain | D010149 | — | G89.18 | — | 2 | — | — | 3 | 5 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 2 | — | — | 2 | 4 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | 3 | 4 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | 2 | — | — | 1 | 3 |
Show 52 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Headache | D006261 | — | R51 | 2 | — | — | — | 4 | 6 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 2 | — | — | — | 2 | 4 |
| Tobacco use disorder | D014029 | — | F17 | 3 | — | — | — | 1 | 4 |
| Smoking | D012907 | EFO_0004318 | — | 3 | — | — | — | 1 | 4 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | 2 | — | — | — | 1 | 3 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | 2 | — | — | — | 1 | 3 |
| Obstructive lung diseases | D008173 | — | — | 1 | — | — | — | 2 | 3 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 2 | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | — | — | — | — | 2 |
| Sclerosis | D012598 | — | — | 2 | — | — | — | — | 2 |
Show 44 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Back pain | D001416 | — | M54 | — | — | — | — | 13 | 13 |
| Low back pain | D017116 | — | M54.5 | — | — | — | — | 12 | 12 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | — | 6 | 6 |
| Hypotrichosis | D007039 | — | — | — | — | — | — | 4 | 4 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | — | — | — | — | 4 | 4 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | — | — | — | 4 | 4 |
| Radiculopathy | D011843 | — | M54.1 | — | — | — | — | 3 | 3 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 3 | 3 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 3 | 3 |
| Post-traumatic headache | D051298 | — | G44.3 | — | — | — | — | 3 | 3 |
Show 148 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methyl salicylate |
| INN | — |
| Description | Methyl salicylate is a benzoate ester that is the methyl ester of salicylic acid. It has a role as a flavouring agent, a metabolite and an insect attractant. It is a benzoate ester, a member of salicylates and a methyl ester. It is functionally related to a salicylic acid. |
| Classification | Small molecule |
| Drug class | anti-inflammatory agents (salicylic acid derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)c1ccccc1O |
Identifiers
| PDB | — |
| CAS-ID | 119-36-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL108545 |
| ChEBI ID | 31832 |
| PubChem CID | 4133 |
| DrugBank | — |
| UNII ID | — |
Target
Agency Approved
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Alternate
TRPA1
TRPA1
Organism
Homo sapiens
Gene name
TRPA1
Gene synonyms
ANKTM1
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily A member 1
Protein synonyms
ankyrin-like with transmembrane domains 1, Ankyrin-like with transmembrane domains protein 1, p120, Transformation-sensitive protein p120, Wasabi receptor
Uniprot ID
Mouse ortholog
Trpa1 (277328)
transient receptor potential cation channel subfamily A member 1 (Q8BLA8)
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Estimated US medical usage
Methyl salicylate
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Menthol
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Methyl salicylate
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Trends
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Safety
Black-box Warning
Black-box warning for: Caplyta, Diclovix m, Fenovar, Lumason, Orthaphen, Varophen
Adverse Events
Top Adverse Reactions
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549,690 adverse events reported
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