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Drug ReportsMethyl salicylate
Methyl salicylate
Salonpas (methyl salicylate) is a small molecule pharmaceutical. Methyl salicylate was first approved as Salonpas on 2008-02-20. It is used to treat acute pain, arthritis, back pain, contusions, and inflammation amongst others in the USA. It is known to target transient receptor potential cation channel subfamily A member 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
Trade Name
FDA
EMA
Combinations
Salonpas
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Menthol
+
Methyl salicylate
Tradename
Company
Number
Date
Products
SALONPASHisamitsu PharmaceuticalN-022029 OTC2008-02-20
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
10% methyl salicylate pain relief patchC2002632024-06-27
1st medxpatchC2002632024-10-31
365 whole foods market anticavity/antigingivitis mouthwashOTC monograph not final2022-05-12
5kind dmsoC2002632025-08-04
701 dieda zhengtong yaogao medicatedOTC monograph not final2019-11-13
701 dieda zhengtong yaogao medicated plasterOTC monograph not final2014-06-26
abejas y viboras roll onC2002632025-07-22
advanced antiseptic citrusC2002632025-02-20
advanced citrus antisepticC2002632025-01-10
advil targeted reliefC2002632024-02-08
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
arthritisEFO_0005856D001168M05-M14
inflammationMP_0001845D007249—
acute pain—D059787R52
sprains and strains—D013180—
skin diseases—D012871L00-L99
contusions—D003288T14.8
back pain—D001416M54
muscle cramp—D009120—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Menthol / Methyl Salicylate, Salonpas, Hisamitsu Pharm Co
88096152030-01-03DP
92331842027-08-01DP
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
435 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ankle injuriesD016512—S93.4———1—1
Sprains and strainsD013180—————1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMethyl salicylate
INN—
Description
Methyl salicylate is a benzoate ester that is the methyl ester of salicylic acid. It has a role as a flavouring agent, a metabolite and an insect attractant. It is a benzoate ester, a member of salicylates and a methyl ester. It is functionally related to a salicylic acid.
Classification
Small molecule
Drug classanti-inflammatory agents (salicylic acid derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COC(=O)c1ccccc1O
Identifiers
PDB—
CAS-ID119-36-8
RxCUI—
ChEMBL IDCHEMBL108545
ChEBI ID31832
PubChem CID4133
DrugBank—
UNII ID—
Target
Agency Approved
No data
Alternate
TRPA1
TRPA1
Organism
Homo sapiens
Gene name
TRPA1
Gene synonyms
ANKTM1
NCBI Gene ID
8989
Protein name
transient receptor potential cation channel subfamily A member 1
Protein synonyms
ankyrin-like with transmembrane domains 1, Ankyrin-like with transmembrane domains protein 1, p120, Transformation-sensitive protein p120, Wasabi receptor
Uniprot ID
O75762
Mouse ortholog
Trpa1 (277328)
transient receptor potential cation channel subfamily A member 1 (Q8BLA8)
Variants
No data
Financial
Revenue by drug
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Orkambi – Vertex Pharmaceuticals
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Oxlumo – Alnylam Pharmaceuticals
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Estimated US medical usage
Methyl salicylate
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Menthol
Total medical expenditures per year (USD, in millions)
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Methyl salicylate
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,952 documents
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Safety
Black-box Warning
Black-box warning for: Caplyta, Diclovix m, Fenovar, Lumason, Orthaphen, Varophen
Adverse Events
Top Adverse Reactions
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549,690 adverse events reported
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